The State Department says Tillerson heads to Beijing on Thursday. His talks with senior Chinese leaders will also cover trade and investment.
It will be Tillerson's second visit to China and comes amid escalating tensions between the U.S. and North Korea. Tillerson went for the first time to Beijing in March.
The department says that the visit reaffirms the Trump administration's commitment to enhance U.S. economic and security interests in the Asia-Pacific region.
Trump is expected to travel to the region this fall.