V.J. King scored 17 points and Deng Adel added 16, including eight during No. 12 Louisville's 10-0 run to close the first half in a 91-58 win over William and Mary.
The host Cardinals (2-0) initially struggled against the Tribe's up-tempo style, going scoreless for 3:06 and allowing W&M to pull to 34-31 with 2:13 remaining in the first half. Adel took charge over the final 1:31 with five free throws and a 3-pointer during the spurt that gave the Cardinals some space entering the break.
Kentucky native Omar Prewitt and Nathan Knight had 14 points apiece for the Tribe, which shot 6 of 29 from 3-point range in losing their first meeting with Louisville in 64 years.
"Their athleticism, their length really bothered us a good bit tonight," William and Mary coach Tony Shaver told Tribe Athletics. "We're not in that class. We're not at that level. This team really needs to get better at this time of the year."
The Tribe will host Presbyterian 7 p.m. Saturday.