Vanderbilt University

Prostate cancer& dementia: Do hormone blockers boost risks?

Hormone-blocking drugs for prostate cancer may increase men's chances for developing dementia, a large study suggests, but researchers say the results aren't conclusive enough to recommend avoiding a treatment that can improve survival.

Cancer patients who used the drugs faced about double the chances of being diagnosed with dementia over five years, compared with nonusers. The actual risk of dementia, though, was quite low for all the men.

The researchers analyzed 20 years of electronic health records for almost 9,300 prostate cancer patients treated at Stanford University's health system. About 20 percent of the men were given hormone blockers, which lower levels of...