Scripps Research Institute

Expanding DNA's alphabet lets cells produce novel proteins

Scientists are expanding the genetic code of life, using man-made DNA to create a semi-synthetic strain of bacteria — and new research shows those altered microbes actually worked to produce proteins unlike those found in nature.

It's a step toward designer drug development.

One of the first lessons in high school biology: All life is made up of four DNA building blocks known by the letters A, T, C and G. Paired together, they form DNA's ladder-like rungs. Now there's a new rung on that ladder.

A team at The Scripps Research Institute in La Jolla, California, expanded the genetic alphabet, creating two artificial DNA "letters" called X and Y. A few years...

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