Daniel Carlson missed two field goals in overtime, including one from 35 yards as time expired, and the Vikings (1-0-1) had to settle for a 29-29 tie with the Packers (1-0-1) after rallying from a late 13-point deficit on Sunday.
The rookie's final attempt went to the right of the uprights, just like his kick from 49 yards earlier in overtime.
Packers kicker Mason Crosby matched a career high with five field goals, but his potential game winner from 52 yards went wide left as time expired in regulation.
"It's disappointing when you've got an opportunity to win the football game there at the end and you come up with a tie. It's better than a loss," Vikings coach Mike Zimmer said.
The result at Lambeau Field overshadowed memorable performances from both quarterbacks.
Packers quarterback Aaron Rodgers played with a brace on his injured left knee and went 30 of 42 for 281 yards and a score.
But a mishandled handoff with 5:17 left in overtime cost the Packers a chance at another long field goal attempt. Rodgers recovered the fumble on second-and-1 at the 37, and he was sacked on third down to push Green Bay back to the 47.
"Close to an 'L.' Doesn't feel great," Rodgers said about the tie.
The Vikings’ Kirk Cousins threw for 425 yards and four touchdowns, including three in the fourth quarter. He also threw an interception to Ha Ha Clinton-Dix after the ball bounced off the hands of Laquon Treadwell with 2:13 left.
49ers 30, Lions 27: Jimmy Garoppolo threw two touchdown passes, Matt Breida ran for 138 yards and the host 49ers (1-1) bounced back from a season-opening loss. Matthew Stafford was much sharper than he was last week for the Lions (0-2) when he threw four interceptions. He went 34 for 53 for 347 yards, three touchdowns and no interceptions.